Solute carrier family 30 member 9 (SLC30A9)

Solute carrier family 30 member 9 (SLC30A9) is a **mitochondrial zinc transporter** that exports Zn2+ from mitochondria to the cytosol, helping maintain intracellular zinc homeostasis and ensuring normal mitochondrial morphology and function[1][2][3][5][7]. SLC30A9 is localized to the mitochondrial membrane and operates as a proton-coupled zinc antiporter, utilizing the mitochondrial proton gradient to export zinc ions. Loss of SLC30A9 results in mitochondrial zinc overload, swelling, impaired mitochondrial metabolism, and is associated with neurodegenerative and developmental disorders, such as Birk-Landau-Perez syndrome. In addition to its main transporter function, SLC30A9 has minor roles as a nuclear receptor coactivator and may influence Wnt-responsive gene transcription. SLC30A9 is evolutionarily conserved and essential for organismal health[1][2][4][5][7].

Other names

ZnT-9Zinc transporter 9ZNT9Proton-coupled zinc antiporter SLC30A9, mitochondrialHuman embryonic lung proteinGRIP1-dependent nuclear receptor coactivatorC4orf1HUELGAC63BILAPES

Drugs targeting this molecule would likely act as **inhibitors or agonists** of mitochondrial zinc export activity, altering intracellular/mitochondrial zinc distribution; however, no approved or experimental drugs are specifically referenced in current literature[2][1][5].