Solute carrier family 33 member 2 (SLC33A2)

Solute carrier family 33 member 2 (SLC33A2, MFSD3) is a protein classified as a putative membrane-bound transporter belonging to the major facilitator superfamily (MFS), often termed an "atypical SLC" due to its sequence similarity to other SLCs but its orphan status regarding substrate specificity, mechanism, and physiological role[1][2]. MFSD3 shares evolutionary origin and sequence identity with SLC33A1 (the acetyl-CoA transporter), suggesting it may transport organic molecules, potentially acetyl-CoA, but its substrates and cellular roles remain to be elucidated[1]. The gene is expressed broadly in neurons and responsive to metabolic changes, hinting at possible involvement in regulation of energy homeostasis or metabolic adaptation, though direct functional and disease associations are unconfirmed at present[1][2].

Other names

Major facilitator superfamily domain-containing protein 3MFSD3SLC33A2solute carrier family 33 member 2