Solute carrier family 35 member D2 (SLC35D2)

Solute carrier family 35 member D2 (SLC35D2) is a nucleotide sugar transporter located in the Golgi apparatus that exchanges UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the Golgi lumen in exchange for UMP. This process provides essential nucleotide sugars for glycosyltransferases, enabling the biosynthesis of glycosaminoglycans and other glycoconjugates. SLC35D2 is part of the SLC35 nucleotide sugar transporter family, showing approximately 50% identity with SLC35D1 and is critical for normal glycosylation processes in humans. Genetic variants in SLC35D2 have been associated with disorders involving defective glycosylation and immune function. No known drugs directly target SLC35D2 as of the current literature, and there are no established clinical biomarkers or mechanisms of action involving pharmacological modulation of this transporter. Dysfunction in SLC35D2 can result in significant congenital disorders and altered immune responses.

Other names

UGTrel8SQV7LUDP-galactose transporter-related protein 8Homolog of Fringe connection protein 1Nucleotide sugar transporter SLC35D2SQV7-like proteinHFRC1fringe connectionsolute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2