Solute carrier family 35 member E1 (SLC35E1)

Solute carrier family 35 member E1 (SLC35E1) is a hydrophobic membrane protein belonging to the SLC35 subfamily of the SLC transporter superfamily[2]. The SLC35 family primarily comprises nucleotide sugar transporters that mediate the transport of nucleotide sugars and adenosine 3'-phospho 5'-phosphosulfate from the cytosol to the endoplasmic reticulum and Golgi apparatus, supporting proper glycosylation and sulfation of proteins, lipids, and proteoglycans[2]. Unlike well-characterized SLC35 members, the exact substrate and transport function for SLC35E1 remain unidentified; however, it is highly conserved, and mutations in key substrate-binding residues (e.g., lysine 142) impair its function[2]. Functionally, SLC35E1 has been shown to play a role in nuclear egress of virions during HSV-1 infection, meaning it facilitates the release of viral particles from the infected cell nucleus[2]. While related families are validated drug targets, and SLC proteins comprise ~20% of all membrane proteins, there are no drugs or biomarker applications specific to SLC35E1 at this time[2][1]. SLC35E1 is therefore best classified as a potential transporter and an accessory viral effector protein, with growing interest in its role in viral infection biology and possible involvement in glycosylation pathways, but with limited data on its therapeutic targeting, endogenous substrates, or disease implications outside of viral infection[2].

Other names

SLC35E1PSEC0038FLJ14251