Solute carrier family 35 member E3 (SLC35E3)

SLC35E3 encodes a putative membrane transporter belonging to the solute carrier 35 family, broadly predicted to facilitate nucleotide-sugar transmembrane transport activity, possibly in an antiporter capacity[2][3][4][7][8]. The protein is expressed ubiquitously and mainly localized to membranes, particularly in the Golgi apparatus[2][7][8]. SLC35E3 is notable for its upregulation in bladder cancer, where it has been used as part of gene expression signatures to distinguish tumor tissue, suggesting diagnostic potential[5][7]. It is also associated with congenital disorders of glycosylation, type Iic[7]. However, its detailed functional biochemistry, physiological substrates, and clinical relevance as a therapeutic drug target remain largely uncharacterized in the literature.

Other names

BLOV1bladder cancer-overexpressed gene 1 proteinUNQ3043/PRO9859