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Solute carrier family 35 member E4 (SLC35E4)
- Target
- SLC35E4
- Molecular classification
- Transporter, Solute carrier family (SLC), Nucleotide sugar transporter (putative, orphan SLC35 subfamily)
01
Overview
SLC35E4 is a putative nucleotide sugar transporter and member of the solute carrier family 35 (subfamily E) of membrane proteins. It localizes predominantly to the Golgi apparatus and is predicted to mediate transmembrane transport processes, potentially via an antiporter mechanism. The protein’s precise substrate and physiological function remain undefined, and functional characterization is limited; it is classified as an orphan transporter within the SLC35 family. Disease associations are currently minimal, and no drugs or clinical interventions directly interact with SLC35E4.
- Other names
- SLC35E4Solute carrier family 35 member E4solute carrier family 35 member E4
02
Mechanism of action
No drugs are known to target SLC35E4; for the SLC35 family, the mechanism is typically transport of nucleotide-conjugated sugars into the Golgi lumen, but SLC35E4’s substrate and exact mechanism are currently unknown
03
Biological functions
Transmembrane transportGolgi apparatus functionPutative antiporter activity (exchange of nucleoside monophosphates for nucleoside diphosphate-conjugated sugars, based on family function)
04
Disease associations
Dimethylglycine dehydrogenase deficiency (listed in one database, but direct mechanistic involvement is not established)
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