Solute carrier family 35 member F2 (SLC35F2)

Solute carrier family 35 member F2 (SLC35F2) is a membrane-bound transporter and part of the nucleotide sugar transporter family in the SLC superfamily[5][3]. It is the only known high-specificity transporter for the micronutrient nucleobase queuine and the nucleoside queuosine, both acquired from the gut microbiome and incorporated into transfer RNAs to regulate translation fidelity and cellular adaptation to stress[1]. SLC35F2 is upregulated in multiple cancers, including lung adenocarcinoma, papillary thyroid carcinoma, bladder, and pancreatic cancers, correlating with aggressive disease features, metastasis, and poor patient prognosis[2][3][5]. It modulates cell proliferation, migration, invasion, regulates apoptosis and the p53 pathway, and plays a role in the uptake of specific anticancer drugs such as YM155[7][3]. Expression and activity of SLC35F2 are closely linked to cancer biology, making it a potential biomarker and therapeutic target for patient stratification and intervention.

Other names

FLJ13018HSNOV1LSCC-3SLC35F2lung squamous cell cancer related protein LSCC-3

Drug influx transporter (e.g., SLC35F2 mediates YM155 uptake into cells) Substrate-selective nucleotide transport (for queuine and queuosine only)