Solute carrier family 35 member F3 (SLC35F3)

Solute carrier family 35 member F3 (SLC35F3) is a membrane transporter protein that facilitates the intracellular transport of thiamine (vitamin B1) across cellular and possibly mitochondrial membranes[1][4][6]. It is encoded by the SLC35F3 gene, located on chromosome 1q42.2, and is predominantly expressed in adult cerebellum and other tissues[2][4]. SLC35F3 is classified as a member of the SLC35 family of solute carriers, specifically as a putative thiamine transporter, and plays a vital role in cellular thiamine homeostasis, which is essential for glucose metabolism and energy production[2][4]. Genetic variants in SLC35F3 have been associated with the regulation of blood pressure and the risk of hypertension, especially among certain populations[2][4][5]. The gene has also been linked to classical thiamine deficiency disorders (beriberi), due to its role in thiamine uptake[1][4]. SLC35F3 is not directly targeted by any approved therapeutics; however, thiamine acts as its physiological substrate. There are no major reported safety concerns for drug targeting of SLC35F3, but loss-of-function mutations may increase the risk of metabolic and cardiovascular diseases due to impaired thiamine transport.

Other names

FLJ37712Thiamine transporter SLC35F3Putative thiamine transporter SLC35F3SLC35F3phSLC35F3Q8IY50

Facilitates thiamine uptake into cells, including mitochondria, contributing to cellular energy metabolism