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Solute carrier family 35 member F6 (SLC35F6)

Target: SLC35F6
Molecular classification: Transporter, Transmembrane protein

Overview

Solute carrier family 35 member F6 (SLC35F6) is a human transmembrane protein belonging to the solute carrier (SLC) superfamily, specifically classified as a transporter. It is encoded by the SLC35F6 gene and commonly referred to by aliases including ANT2BP, C2orf18, and TANGO9[1][5]. SLC35F6 participates in transmembrane transport, maintenance of mitochondrial membrane potential, and protein binding. It negatively regulates mitochondrial outer membrane permeabilization involved in apoptotic signaling, and is implicated in promoting pancreatic ductal adenocarcinoma cell survival by supporting mitochondrial function[2][7]. While considered a transporter and potential cancer target, there are no recognized drugs, safety concerns, or clinical biomarkers tied specifically to SLC35F6 in the current literature.

Other names: ANT2BPC2orf18TANGO9Transport and Golgi organization 9 homologANT2-binding proteintransmembrane protein C2orf18UNQ3047/PRO9863FLJ20555

Biological functions

Transmembrane transporter activity[2][5]Maintenance of mitochondrial membrane potential[7][8]Protein binding[1][6]Negative regulation of mitochondrial outer membrane permeabilization involved in apoptosis[2][5]

Disease associations

Cancer (notably, promotes pancreatic ductal adenocarcinoma cell survival and mitochondrial activity)[7][8]Other (potential involvement in cell survival via mitochondria)

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