Solute carrier family 35 member H1 (SLC35H1)

Solute carrier family 35 member H1 (SLC35H1) is a nucleotide sugar transporter protein primarily localized in the membrane of the Golgi apparatus and endoplasmic reticulum[1][4]. It regulates glycosylation by shuttling activated sugars from the cytosol into organellar lumens, thus supporting cellular glycoprotein synthesis and processing. SLC35H1 expression is regulated by oxygen tension, with increased levels observed in hypoxic contexts, including trophoblast cells. It has also been highlighted for its overexpression in certain ovarian tumors, suggesting a role in cancer development and potential use as a biomarker[4]. The molecular mechanisms, clinical impact, and therapeutic modulation remain incompletely understood, as direct drug interactions or modulatory strategies are not yet established in the literature[2][4][1]. If greater granularity or recent drug development data are needed, further database queries or wet-lab literature reviews may be warranted given the limited clinical translation to date.

Other names

SLC35C2OVCOV1Ovarian cancer-overexpressed gene 1 proteinC20orf5CGI-15BA394O2.1bA394O2.1

None available, as no drugs targeting SLC35H1 have clinical characterization or published mechanistic data in relation to this transporter[2][4].