Solute carrier family 37 member 2 (SLC37A2)

Solute carrier family 37 member 2 (SLC37A2) is an endoplasmic reticulum-associated transporter that functions as a phosphate-linked glucose-6-phosphate (G6P) antiporter, catalyzing the exchange of G6P and inorganic phosphate across membranes[1][2][4][5]. SLC37A2 differs from SLC37A4 (the canonical G6P transporter in gluconeogenic tissues) in that it does not couple to glucose-6-phosphatase and its function is not inhibited by chlorogenic acid[1][2][4]. SLC37A2 is highly expressed in macrophages, spleen, and thymus, with expression markedly upregulated during macrophage differentiation[4]. In bone, SLC37A2 is essential for normal osteoclast function, localizing to lysosome-related organelles involved in bone resorption; knockout in mice results in increased bone mass due to impaired osteoclast activity[3]. Its precise physiological substrate remains incompletely defined, and its role in human disease is under investigation, but it has emerged as a potential therapeutic target for metabolic bone disorders[3][4].

Other names

Glucose-6-phosphate exchanger SLC37A2SLC37A2FLJ00171SPX2Sugar-phosphate exchange protein 2pp11662Solute carrier family 37 (glucose-6-phosphate transporter) member 2Solute carrier family 37 (glycerol-3-phosphate transporter) member 2Sugar phosphate exchanger 2

Not established for drugs (no approved inhibitors or modulators).