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Target intelligence / Profile preview
Solute carrier family 39 member 12 (SLC39A12)
- Target
- SLC39A12
- Molecular classification
- Zrt-/Irt-like protein (ZIP) family, Solute carrier family, Transporter
01
Overview
SLC39A12, also known as ZIP12, is a zinc transporter protein belonging to the ZIP family. It facilitates the import of Zn²⁺ into the cytoplasm and is highly expressed in the nervous system. ZIP12 plays crucial roles in neural development, synaptic zinc regulation, pulmonary vascular homeostasis, and mitochondrial function. Genetic variations in SLC39A12 are associated with altered brain metal homeostasis and neurological disease risk. It represents a potential drug target for managing pulmonary hypertension by modulating vascular smooth muscle cell proliferation through zinc signaling pathways.
- Other names
- ZIP12Zinc transporter ZIP12
02
Mechanism of action
Modulation of Zn²⁺ transport across cell membranes.
03
Biological functions
Zn²⁺ importMetal ion transportNeuronal differentiationSynaptic zinc homeostasisVascular remodelingRegulation of CREB activationMitochondrial functionRedox balance
04
Disease associations
Pulmonary hypertensionNeurological diseaseNeurodegenerative disease riskPremature aging
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