Solute carrier family 39 member 14 (SLC39A14)

Solute carrier family 39 member 14 (SLC39A14; also known as ZIP14) is a **metal ion transporter** in the ZIP family, primarily facilitating the uptake of zinc, manganese, iron, and cadmium into cells[2][3]. SLC39A14 is widely expressed, including in liver, pancreas, muscle, adipose tissue, and the brain[2][3][7]. It helps maintain systemic and cellular metal ion homeostasis and plays essential roles in **regulating glucose metabolism, insulin secretion, immune signaling, and systemic growth**[1][2][4][5]. ZIP14 is upregulated during inflammation and is involved in the body's acute-phase response, modulating signaling pathways such as GPCR-mediated cAMP generation, NF-κB, and STAT3[4][5][6]. Germline mutations in SLC39A14 can cause **hereditary manganese accumulation and neurotoxicity**, while its dysregulation influences susceptibility to metabolic inflammation, obesity, and cachexia[3][5][7]. As a transporter, SLC39A14 is a potential therapeutic target in disorders of metal ion metabolism and related systemic diseases.

Other names

ZIP14Metal cation symporter ZIP14KIAA0062LZT-Hs4NET34ZIP-14LIV-1 subfamily of ZIP zinc transporter 4Zrt- and Irt-like protein 14zinc transporter 14HCINHMNDYT2cig19

Not applicable for approved drugs; mechanisms studied involve alteration of metal transport to modulate intracellular zinc, iron, or manganese levels that impact signaling pathways (e.g., GPCR-cAMP-CREB pathway, inhibition of phosphodiesterases, modulation of insulin signaling)[4].