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Target intelligence / Profile preview
Choline Transporter-Like Protein 4 (CTL4)
- Target
- CTL4
- Molecular classification
- Transporter, Solute Carrier Family
01
Overview
Choline transporter-like protein 4 (CTL4), encoded by the SLC44A4 gene, is a choline transporter involved in both neuronal and non-neuronal acetylcholine synthesis. In the olivocochlear bundle, it supports hair cell function and protects against acoustic injury. Outside the nervous system, CTL4 mediates acetylcholine synthesis and secretion in tissues like lung and colon cancer cells, offering a potential target for modulating cholinergic signaling without affecting neuronal pathways. Its role in non-neuronal acetylcholine production is particularly relevant for cancer research and potential therapeutic interventions in immune and degenerative diseases.
- Other names
- C6orf29NG22TPPTSolute carrier family 44 member 4DFNA72hTPPT1
02
Biological functions
Transmembrane transport of cholineAcetylcholine secretionPhosphatidylcholine biosynthetic processAcetylcholine biosynthetic processCholine uptake
03
Disease associations
Hearing LossCancerImmune diseasesDegenerative diseases
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