Solute carrier family 50 member 1 (SLC50A1)

Solute carrier family 50 member 1 (SLC50A1) encodes a broadly expressed transmembrane sugar transporter, also known as SWEET1, that mediates glucose and possibly other sugar transport across cellular membranes[1][3][4]. It is the only member of the SWEET transporter family in humans, and has roles in carbohydrate transport in various tissues, including potential involvement in mammary gland function and embryogenesis in homologous systems[1][3][4]. SLC50A1 expression is significantly upregulated in human breast cancer, with serum and tissue levels linked to estrogen receptor and HER2 status and unfavorable prognosis[2]. Elevated serum SLC50A1 can serve as a diagnostic and prognostic biomarker for breast cancer, though its precise transport mechanism and therapeutic potential remain areas of ongoing study[2][4]. SLC50A1 may also play a role in other diseases such as Parkinson's disease and angiomyoma, but limited evidence exists for current targeted pharmacological interventions[4].

Other names

Sugar transporter SWEET1HsSWEET1RAG1AP1SCPSWEET1slvStromal cell proteinRAG1-activating protein 1probable sugar transporter RAG1AP1solute carrier family 50 (sugar transporter) member 1stromal cell protein

Not fully elucidated; potential involvement in sugar efflux and cellular carbohydrate supply[1][2]. Amplification may affect sensitivity to certain cancer therapies (e.g., ABL1 inhibitors)[2].