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Target intelligence / Profile preview
Solute Carrier Family 6 Member 2 (SLC6A2)
- Target
- SLC6A2
- Molecular classification
- Transporter, Solute Carrier Family
01
Overview
Solute carrier family 6 member 2 (SLC6A2) encodes the norepinephrine transporter (NET), a transmembrane protein responsible for the reuptake of norepinephrine from the synaptic cleft. NET plays a crucial role in regulating the concentration and duration of norepinephrine signaling, influencing various physiological processes, including attention, mood, and cardiovascular function. Inhibition of NET is a common mechanism of action for several antidepressant and ADHD medications.
- Other names
- Norepinephrine transporterNETNATNoradrenaline transporter
02
Mechanism of action
Inhibition of norepinephrine reuptake
03
Biological functions
Neurotransmitter transportRegulation of synaptic norepinephrine levelsNorepinephrine reuptake
04
Disease associations
Attention-deficit/hyperactivity disorder (ADHD)DepressionPostural orthostatic tachycardia syndrome (POTS)Cardiovascular diseaseAnxiety disorders
05
Safety considerations
Cardiovascular effects (e.g., increased heart rate, blood pressure)AnxietyInsomniaDrug interactionsPotential for misuse/abuse (for some inhibitors)
06
Interacting drugs
Atomoxetine
5 more in the full profile.
07
Biomarkers
Genetic variations in SLC6A2Plasma norepinephrine levelsNET availability in brain imaging studies (e.g., SPECT, PET)
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