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Solute carrier family 6 member 7 (SLC6A7)
- Target
- SLC6A7
- Molecular classification
- Transporter, Neurotransmitter:sodium symporter family, GABA neurotransmitter gene family
01
Overview
SLC6A7 encodes a high-affinity sodium- and chloride-dependent L-proline transporter protein. This transporter is primarily responsible for the active uptake of L-proline into neurons, regulating levels of this amino acid at excitatory synapses. Its activity influences excitatory neurotransmission; alterations or dysfunctions could impact neurological processes or diseases involving glutamatergic signaling or amino acid metabolism. Enkephalins can competitively inhibit PROT/SLC6A7, suggesting potential cross-talk between opioid peptides and proline-mediated signaling pathways in the CNS.
- Other names
- Proline TransporterL-proline transporterPROTHPROT
02
Mechanism of action
Competitive inhibition of L-proline transport
03
Biological functions
L-proline transportRegulation of excitatory neurotransmissionModulation of synaptic function
04
Disease associations
Neurological disorders involving glutamatergic signalingDisorders involving amino acid metabolism
05
Interacting drugs
Enkephalins (competitive inhibitors)
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