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Solute Carrier Family 6 Member 9 (SLC6A9)
- Target
- SLC6A9
- Molecular classification
- Solute Carrier Family 6 (SLC6), Transporter, Membrane protein
01
Overview
Solute carrier family member SLC6A9 encodes an essential neuronal transporter regulating inhibitory neurotransmission via control over extracellular levels of the amino acid transmitter *glycine*. It represents both an important physiological regulator within neural circuits and an emerging drug target.
- Other names
- Sodium- and chloride-dependent glycine transporter 1GlyT1
02
Mechanism of action
GlyT1 inhibition
03
Biological functions
Amino acid:sodium symporter activityGlycine reuptakeTermination of inhibitory neurotransmissionRegulation of extracellular glycine levelsRegulation of NMDA receptor function
04
Disease associations
Glycine encephalopathy with normal serum glycine (GlyT1 encephalopathy)SchizophreniaCognitive disorders
05
Interacting drugs
Bitopertin
5 more in the full profile.
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