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Target intelligence / Profile preview
Solute Carrier Family 7 Member 11 (SLC7A11)
- Target
- SLC7A11
- Molecular classification
- Transporter, Solute Carrier
01
Overview
SLC7A11, also known as xCT, is a protein that functions as the light chain subunit of system Xc-, a sodium-independent cystine/glutamate antiporter. It imports extracellular cystine into cells in exchange for exporting intracellular glutamate. Cystine is then reduced to cysteine, a precursor for glutathione (GSH) synthesis, which protects cells from oxidative stress and ferroptosis. SLC7A11 is highly expressed in cancer cells, where it promotes tumor growth by enhancing antioxidant capacity. It is also involved in neurological disorders due to its role in glutamate release. SLC7A11 is regulated by transcriptional factors like NRF2 and p53, as well as epigenetic and post-translational mechanisms.
- Other names
- xCTCystine/Glutamate TransporterAmino Acid Transport System Xc-Calcium Channel Blocker Resistance Protein CCBR1Solute Carrier Family 7 (Anionic Amino Acid Transporter Light Chain, Xc- System), Member 11
02
Mechanism of action
Inhibition of cystine/glutamate antiporter activity, leading to decreased glutathione synthesis and increased oxidative stress.
03
Biological functions
Cystine transportGlutamate transportGlutathione biosynthesisRedox homeostasisCell proliferation
04
Disease associations
CancerCystinuriaLysinuric protein intoleranceNeurological disordersEpilepsyNeurodegeneration
05
Safety considerations
Potential for neuronal toxicity due to excessive glutamate releaseOff-target effects of inhibitors on other solute carriers
06
Biomarkers
SLC7A11 expression levels in tumor tissue
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