Solute carrier family 7 member 6 (SLC7A6)

Solute carrier family 7 member 6 (SLC7A6, also known as Y+L amino acid transporter 2 or Y+LAT2) is a plasma membrane transporter that forms a heterodimeric complex with SLC3A2 (4F2hc). It mediates the electroneutral exchange of cationic amino acids (such as L-arginine and L-lysine) for neutral amino acids (such as L-leucine and L-glutamine), with sodium-dependence for neutral amino acids. SLC7A6 is important for cellular uptake and efflux of amino acids, nitric oxide production, and ammonia clearance. Its overexpression is linked with enhanced amino acid uptake and signaling pathways promoting cancer growth. Dysfunction is implicated in disorders like lysinuric protein intolerance and cystinuria[1][2][3][4].

Other names

Y+L amino acid transporter 2Y+LAT2y+LAT-2KIAA0245cationic amino acid transporter, y+ systemy(+)L-type amino acid transporter 2LAT-2LAT3

Transports/exchanges cationic and neutral amino acids across the plasma membrane, either sodium-independent (for cationic) or sodium-dependent (for neutral), functioning as an antiporter[1][2][3][4].