Solute carrier family 9 member B1 pseudogene 2 (SLC9B1P2)

Solute carrier family 9 member B1 pseudogene 2 (SLC9B1P2, also known as NHEDC1P2), is a human pseudogene derived from the SLC9B1 gene, part of the Na+/H+ exchanger (NHE) family[1][3]. Unlike functional SLC9B1 or other NHE genes, SLC9B1P2 does not encode a functional protein or demonstrate transporter, receptor, or enzyme activity, and is not a therapeutic or diagnostic target. Its main relevance is genomic, as an annotated pseudogene found on chromosome 2p11.1[3]. There is no evidence of biological or pathophysiological function, clinical utility, drug interaction, or safety concerns related to SLC9B1P2. Key Points: - SLC9B1P2 is clearly designated a pseudogene in both nomenclature and gene databases[1][3]. - Pseudogenes are genomic sequences similar to known genes but do not produce functional proteins. - No evidence identifies SLC9B1P2 as a gene with protein products, receptor function, or involvement in cellular or disease pathways[1][3]. - It should not be considered a drug target or receptor, despite the overlapping nomenclature with functional SLC9B family members[1][3]. If a true, active Na+/H+ exchanger is the intended target (such as "solute carrier family 9 member B1" or SLC9B1/NHA1), please specify, as those are functional transporters and may be therapeutic targets[2][4][5].

Other names

NHEDC1P2Na+/H+ exchanger domain containing 1 pseudogene 2solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 pseudogene 2solute carrier family 9, subfamily B (cation proton antiporter 2), member 1 pseudogene 2SLC9B1P2