Solute carrier organic anion transporter family member 1A2 (OATP1A2)

Solute carrier organic anion transporter family member 1A2 is a sodium-independent membrane transporter encoded by the SLCO1A2 gene in humans. It mediates cellular uptake of a variety of endogenous and exogenous organic ions—including bile acids, steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS), bromosulphophthalein, and certain drugs—in tissues such as liver, brain, lung, and intestine. The protein belongs to the SLC21 family (now often referred to as SLCO) and plays a key role in xenobiotic metabolism and pharmacokinetics. Genetic variation in SLCO1A2 has been associated with differences in drug response; it has also been identified as a susceptibility locus for some neurodegenerative diseases.

Other names

SLCO1A2OATPOATP-AOATP1SLC21A3Organic anion-transporting polypeptide 1Sodium-independent organic anion transporterSolute carrier family 21 member 3

Drugs targeting or utilizing this transporter typically act by modulating or relying on its function for cellular uptake and distribution—especially hepatic and intestinal transport—of their active forms or metabolites.