Solute carrier organic anion transporter family member 1B3-1B7 (SLCO1B3-SLCO1B7)

Solute carrier organic anion transporter family member 1B3-1B7 (SLCO1B3-SLCO1B7) is a fusion protein encoded by a naturally occurring readthrough transcript between the SLCO1B3 and SLCO1B7 genes on chromosome 12[1][2][3][6]. It is classified as a member of the organic anion transporting polypeptide (OATP) family and is predominantly expressed in the smooth endoplasmic reticulum of hepatocytes[2]. The transporter facilitates the sodium-independent uptake of organic anions, including steroid conjugates (such as dehydroepiandrosterone sulfate [DHEAS] and 17-beta-glucuronosyl estradiol) and bile acids, into the smooth endoplasmic reticulum for further metabolism[1][2]. Genetic variants in the SLCO1B7-encoded portion of this protein can reduce or abolish transport activity, which may have pharmacogenetic implications and could contribute to disorders such as Rotor-type hyperbilirubinemia and potentially variable drug response[1][2].

Other names

OATP1B3-1B7LST-3TM12SLCO1B3-SLCO1B7 readthrough transcript proteinOrganic anion transporting polypeptide 1B3-1B7Liver specific transporter-3 transmembrane 12Solute carrier organic anion transporter family member 1B3-1B7

Mediates Na(+)-independent uptake of organic anions from cytosol into smooth endoplasmic reticulum for metabolism. Affects intracellular drug distribution and metabolism.