Solute carrier organic anion transporter family member 1B7 (SLCO1B7)

Solute carrier organic anion transporter family member 1B7 (SLCO1B7) is a member of the SLC21A family of solute carriers, formally classified as a putative transporter and pseudogene in humans. It is primarily expressed in the endoplasmic reticulum and plasma membrane of liver cells, and its functional splice variant (LST-3TM12) may contribute to the uptake of organic anions, such as conjugated steroids and bile acids. The gene is notable for its association with pharmacogenomic traits, such as susceptibility to drug-induced neutropenia and myopathy. Unlike other OATP family members (e.g., SLCO1B1, SLCO1B3), it is not considered a functional drug transporter in humans, and thus is generally not a direct therapeutic target for drugs, but may influence drug effects through genetic variation.

Other names

LST3LST3TM12SLC21A21OATP1B7Liver-specific organic anion transporter 3Putative organic anion transporting polypeptide 1B7

Not directly established for drugs, but genetic variants may modify drug metabolism or adverse response via unknown or indirect mechanisms; OATP-type transport (if functional), facilitating cellular uptake of organic anions