Solute carrier organic anion transporter family member 1B7 circular RNA (circSLCO1B7)

circSLCO1B7 is a circular RNA (circRNA) molecule generated through the back-splicing of exons from the Solute Carrier Organic Anion Transporter Family Member 1B7 (SLCO1B7) gene (GeneCards). It primarily functions as a competitive endogenous RNA (ceRNA), acting as a molecular sponge for microRNAs such as miR-502-3p (PMID: 34154567). By sequestering these microRNAs, circSLCO1B7 prevents the degradation of downstream oncogenic targets like HOXA1, thereby promoting cell proliferation, migration, and invasion in malignancies such as colorectal cancer (PMID: 34154567). Its expression is frequently upregulated in cancerous tissues compared to healthy controls, making it a significant player in tumor progression and metastasis. Although no clinical drugs currently target circSLCO1B7, it is a subject of intense research for RNA-based therapeutic interventions, including antisense oligonucleotides and siRNA-mediated knockdown. Additionally, its stability in biological fluids positions it as a promising non-invasive biomarker for cancer diagnosis and prognosis. Understanding the circSLCO1B7-mediated regulatory axes offers potential for developing precision medicine approaches in oncology.

Other names

Circular RNA SLCO1B7hsa_circ_0001535hsa_circ_001535

Acts as a competitive endogenous RNA (ceRNA) by sponging microRNAs (specifically miR-502-3p), which prevents the suppression of oncogenic target genes such as HOXA1, thereby promoting tumor progression (PMID: 34154567).