Solute carrier organic anion transporter family member 4C1 (OATP4C1)

Solute carrier organic anion transporter family member 4C1 (OATP4C1) is a multispecific membrane transporter encoded by the SLCO4C1 gene and located in the basolateral membrane of kidney proximal tubule cells[1][3]. It belongs to the organic anion transporting polypeptide (OATP) family within the solute carrier (SLC) superfamily and facilitates the renal uptake and elimination of a broad range of organic anions, including bile acids, steroid conjugates, thyroid hormones, and many drugs, with digoxin being a clinically significant substrate[1][2][3][4][5]. OATP4C1 plays a key role in drug disposition, especially for substances requiring active tubular secretion, and its function is important for both pharmacokinetics and potential drug-drug interactions, particularly in the context of renal impairment or polypharmacy[1][6].

Other names

SLCO4C1OATP-HOATP-M1OATPXPRO2176SLC21A20

Mediates cellular uptake of drugs and endogenous compounds (by active or facilitated transport across basolateral membranes)