Solute carrier organic anion transporter family member 5A1 (SLCO5A1)

Solute carrier organic anion transporter family member 5A1 (SLCO5A1) is a human membrane protein with 12 transmembrane domains, part of the organic anion transporting polypeptide (OATP) family within the solute carrier (SLC) superfamily[1][3]. It is encoded by the SLCO5A1 gene on chromosome 8 and consists of 848 amino acids[1][3]. SLCO5A1 is expressed in various normal and cancerous tissues, including the brain, heart, skeletal muscle, ovary, and different types of cancer such as breast, prostate, and liver[1][3]. It is most notably found on the plasma membrane of epithelial cells and is upregulated during dendritic cell maturation, suggesting a role in immune cell differentiation[1][3]. Some data link this transporter to hormone uptake in breast cancer and drug resistance in small cell lung cancer, possibly by mediating intracellular drug sequestration rather than direct cellular uptake[3][1]. While its detailed substrate specificity remains under-characterized, SLCO5A1 likely participates in the transport of amphipathic organic anions and may modulate hormone or drug disposition in tissues[5][3]. The transporter is also implicated in developmental disorders such as Mesomelia-synostoses syndrome, potentially through gene haploinsufficiency[1]. SLCO5A1 is considered a non-classical OATP member and is under study for its role in cell shape reorganization, migration, and proliferation, especially in the immune and cancer context[3][1].

Other names

Organic anion transporter polypeptide-related protein 4OATP5A1SLC21A15OATP-RP4OATP-JOATPJOATPRP4Solute carrier family 21 member 15