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Target intelligence / Profile preview
Somatostatin Receptor 1 (SSTR1)
- Target
- SSTR1
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor, Somatostatin receptor subfamily
01
Overview
Somatostatin receptor 1 (SSTR1) is a G protein-coupled receptor (GPCR) that mediates the inhibitory effects of somatostatin on hormone secretion and neuronal activity. It is primarily expressed in the jejunum, stomach, central nervous system, and peripheral tissues. SSTR1 plays roles in various physiological functions including growth hormone release, insulin/glucagon secretion, cell proliferation, gastric acid secretion, angiogenesis, and gastrointestinal motility. While not yet a primary drug target, its broad tissue distribution suggests potential therapeutic applications in metabolic regulation, gastrointestinal function, neurological diseases, and cancer.
- Other names
- SS-1-RSS1-RSS1RSST1SRIF-2
02
Mechanism of action
Gi/o protein-mediated inhibition of adenylyl cyclase activity; Stimulation of phosphotyrosine phosphatase and Na+/H+ exchanger.
03
Biological functions
Inhibition of growth hormone releaseModulation of insulin/glucagon secretionRegulation of cell proliferationInhibition of gastric acid secretionModulation of angiogenesisRegulation of peristalsisInhibition of hormone secretionModulation of neuronal excitabilitySignal transduction
04
Disease associations
Metabolic regulationGastrointestinal function modulationNeurological disease mechanismsCancer biologyNeuroendocrine tumorsAcromegaly
05
Safety considerations
Lack of highly selective ligandsCross-reactivity among somatostatin receptor subtypes
06
Interacting drugs
Somatostatin
2 more in the full profile.
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