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Target intelligence / Profile preview
Somatostatin receptor 3 (SSTR3)
- Target
- SSTR3
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
Somatostatin receptor 3 (SSTR3) is a G protein-coupled receptor that mediates the effects of somatostatin. It is involved in inhibiting hormone secretion, antiproliferative effects, and neuromodulation. SSTR3 is highly expressed in the brain (notably neuronal cilia), pancreatic islets, and anterior pituitary gland. It is targeted by endogenous peptides (somatostatins) and synthetic drugs to modulate hormone release or inhibit tumor growth.
- Other names
- sst3SSTR3 receptor
02
Mechanism of action
Inhibition of adenylyl cyclase via Gi/o proteins; modulation of hormone release; inhibition of tumor growth
03
Biological functions
Neuropeptide bindingSignal transduction activityProtein bindingSomatostatin receptor activityInhibition of hormone secretionAntiproliferative effectsNeuromodulationRegulation of hormone secretionCell proliferation inhibitionModulation of insulin/glucagon secretionGastric acid secretion controlAngiogenesis regulationPeristalsis modulation in the gutNeuronal signaling
04
Disease associations
Endocrine tumorsPituitary disordersMetabolic disorders
05
Safety considerations
Potential for off-target effects due to somatostatin receptor family similarityDevelopment of selective ligands is challenging
06
Interacting drugs
Cortistatin
4 more in the full profile.
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