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Target intelligence / Profile preview
Somatostatin Receptor 5 (SSTR5)
- Target
- SSTR5
- Molecular classification
- GPCR, G protein-coupled receptor, Class A GPCR, Receptor
01
Overview
Somatostatin receptor 5 (SSTR5) is a G protein-coupled receptor that mediates the inhibitory effects of somatostatin on hormone secretion in various tissues. It is highly expressed in the pituitary gland, pancreas, and gastrointestinal tract and plays a key role in regulating the release of growth hormone, adrenocorticotropic hormone, prolactin, insulin, and glucagon. It is a therapeutic target for neuroendocrine tumors and pituitary disorders.
- Other names
- SS-R-VSS‐V‐RSST₅RSST_5_RSST_5SST-V-RSST-VSSTR-VSSTR_05GPR388HGNC:11332
02
Mechanism of action
Upon ligand binding, SSTR5 activates Gi/o proteins, leading to inhibition of adenylyl cyclase, decreased cAMP levels, and suppression of hormone secretion.
03
Biological functions
Signal transductionInhibition of growth hormone (GH) releaseInhibition of adrenocorticotropic hormone (ACTH) releaseInhibition of prolactin releaseInhibition of insulin releaseInhibition of glucagon releaseRegulation of endocrine secretionRegulation of exocrine secretionModulation of intestinal barrier function
04
Disease associations
Neuroendocrine tumorsPituitary disordersAcromegalyPituitary adenomas
05
Interacting drugs
Somatostatin-28
2 more in the full profile.
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