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Somatostatin receptor subtype 3 (SSTR3)

Target: SSTR3
Molecular classification: G protein-coupled receptor, GPCR, Receptor

Overview

Somatostatin receptor subtype 3 (SSTR3) is a class A G protein-coupled receptor (GPCR) that mediates the inhibitory effects of somatostatin on hormone secretion. It is highly expressed in the brain and pancreatic islets and plays roles in neuroendocrine signaling and suppression of basal growth hormone synthesis in pituitary tumors.

Other names: SRIF 1CSomatostatin receptor 28SSR‐28

Mechanism of action

Inhibition of adenylyl cyclase activity via Giα subunits, Modulation of cAMP/PKA signaling pathway, Influencing ion channel activity

Biological functions

Signal transductionInhibition of hormone releaseModulation of cAMP/PKA signaling pathwayRegulation of endocrine/exocrine secretions

Disease associations

Pituitary tumors

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