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Target intelligence / Profile preview
Somatostatin Receptor Subtype 4 (SSTR4)
- Target
- SSTR4
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
Somatostatin receptor subtype 4 (SSTR4) is a G protein-coupled receptor that binds somatostatin. SSTR4 mediates analgesic, anti-inflammatory, and antidepressant effects without significant endocrine actions. It is expressed in the brain, lung, and other tissues and plays a role in learning, memory, and amyloid beta-peptide degradation. SSTR4 is a potential therapeutic target for chronic pain, neurodegenerative diseases, epilepsy, and depression.
- Other names
- SSTR-4SSTR 4
02
Mechanism of action
Gi/o-mediated inhibition of adenylyl cyclase/cAMP pathway; modulation of MAPK cascade; modulation of neuronal excitability; induction of G1 cell cycle arrest; promotion or inhibition of apoptosis
03
Biological functions
Signal transductionAnalgesiaAnti-inflammationCognitive modulationInhibition of hormone secretionInhibition of cell proliferationModulation of neuronal excitability
04
Disease associations
Neurodegenerative diseaseAlzheimer’s diseaseChronic painEpilepsyDepression
05
Safety considerations
Potential for hormonal side effects with non-selective somatostatin analogsTherapeutic challenges related to achieving subtype selectivity
06
Interacting drugs
Somatostatin-14
4 more in the full profile.
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