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Target intelligence / Profile preview
Somatostatin Receptor Type 1 (SSTR1)
- Target
- SSTR1
- Molecular classification
- G protein-coupled receptor, GPCR, Somatostatin receptor subfamily, Receptor
01
Overview
Somatostatin receptor type 1 (SSTR1) is a G protein-coupled receptor that mediates the biological effects of somatostatin. It inhibits the release of various hormones and secretory proteins and is involved in regulating endocrine, neuronal, and gastrointestinal functions. SSTR1 has been implicated as a potential tumor suppressor, with altered expression observed in certain cancers. Synthetic ligands targeting SSTR1 are being investigated for treating endocrine tumors.
02
Mechanism of action
Activation of inhibitory G proteins, decreased cyclic AMP levels, downstream inhibition or modulation of target cellular processes such as hormone secretion or cell proliferation
03
Biological functions
Inhibition of growth hormone releaseModulation of insulin secretionModulation of glucagon secretionRegulation of gastric acid secretionInhibition of peristalsisSignal transduction
04
Disease associations
Cancer
05
Safety considerations
Lack of highly subtype-selective ligands for clinical use
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