SON DNA and RNA binding protein (SON)

SON DNA and RNA binding protein (SON) is a large, ubiquitously expressed nuclear protein with both DNA- and RNA-binding properties[1][2][3][4][5]. SON acts as an essential cofactor for pre-mRNA splicing, particularly for transcripts with weak splice sites, and is a critical regulator of cell cycle genes, DNA repair, genome stability, apoptosis, chromatin modifications, and stem cell pluripotency[1][2][3][4]. It functions as a scaffold in nuclear speckles and facilitates recruitment of splicing factors, especially serine/arginine-rich proteins, to nascent transcripts[2]. SON's DNA-binding capacity contributes to repression of specific viral promoters and the regulation of gene expression[1][3]. Disruption or mutation of SON leads to defective RNA splicing, failed mitosis, impaired genome stability, neurodevelopmental disorders like ZTTK syndrome, and contributes to cancer pathogenesis[1][2][4]. Research implicates SON as a potential therapeutic target for certain cancers and as a node in viral-host interactions, although there are currently no drugs directly targeting it[1][4].

Other names

SONProtein SONC21orf50DBP5KIAA1019NREBPHSPC310HSPC312BASS1NRE-binding proteinDBP-5SON3TOKIMSBax antagonist selected in Saccharomyces 1Negative regulatory element-binding proteinprotein SON

No direct drugs, but SON depletion impairs splicing of cell-cycle and DNA repair genes, affecting cancer cell viability[1][4].\nTheoretical therapeutic strategies: Modulation of SON expression or splicing function for disease treatment, especially in cancers and viral infections[1][4].