Target intelligence / Profile preview

Son of Sevenless homolog 1 (None)

Target: None
Molecular classification: Enzyme, Guanine nucleotide exchange factor (GEF)

Overview

SOS1 is a guanine nucleotide exchange factor (GEF) that activates Ras proteins by catalyzing the exchange of GDP for GTP. It plays a crucial role in cell signaling, controlling cell proliferation, growth, and differentiation. Mutations and dysregulation of SOS1 are implicated in Noonan syndrome and cancer. Recent research has identified druggable pockets on SOS1 leading to potent inhibitors.

Other names: SOS1GINGF

Mechanism of action

Inhibition of SOS1 activity

Biological functions

Signal transductionCell proliferationCell differentiationRegulation of RAS/MAPK pathwayCytoskeleton reorganization

Disease associations

Noonan syndromeCancer

Interacting drugs

BI-3406

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