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Target intelligence / Profile preview
Sonic Hedgehog Signaling Pathway (Shh Pathway)
- Target
- Shh Pathway
- Molecular classification
- Signal Transduction Pathway
01
Overview
The Sonic hedgehog (Shh) signaling pathway is a highly conserved and complex signal transduction cascade that plays a critical role in embryonic development, tissue patterning, and post-embryonic tissue regeneration. It is essential for the regulation of cell growth, differentiation, and the spatial organization of various tissues and organs during development. The pathway is named after its key ligand, Sonic hedgehog (SHH).
- Other names
- SHH pathwayHedgehog signaling pathwayHH pathway
02
Mechanism of action
Inhibition of Smoothened (SMO), leading to downregulation of GLI transcription factors and reduced expression of Shh target genes.
03
Biological functions
Embryonic patterningDevelopmentCNS polarityOrganogenesisTissue repairCell growth regulationCell differentiation
04
Disease associations
CancerBirth defectsHoloprosencephalyEye malformations
05
Safety considerations
Potential for developmental defectsOff-target effects due to pathway's broad role in development and tissue homeostasis
06
Interacting drugs
Smoothened inhibitors
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