Sorbin and SH3 domain-containing protein 1 (SORBS1)

Sorbin and SH3 domain-containing protein 1 (SORBS1) is a multidomain adaptor protein prominent in insulin signaling, cytoskeletal organization, and cell–matrix interaction. It is an 81–142 kDa protein encoded by the SORBS1 gene on chromosome 10q23.3–q24.1, generating several isoforms by alternative splicing. SORBS1 binds to c-Cbl and vinculin, facilitating tyrosine phosphorylation and actin stress fiber formation during insulin stimulation. It regulates glucose uptake in adipose and muscle tissue, participates in focal adhesion dynamics, and acts as a tumor suppressor by limiting cell migration and invasion. Mutations or altered expression are implicated in type 2 diabetes, obesity, and the progression and aggressiveness of several cancers. SORBS1 thus represents a nexus for signal transduction, metabolic regulation, cytoskeletal architecture, and cancer biology.

Other names

CAP (c-Cbl-associated protein)PonsinSH3P12SH3D5KIAA0894KIAA1296SORB1FLAF2R85FLFas-ligand associated factor 2

For drugs that would target SORBS1 (none specifically listed), the expected mechanisms include modulation of insulin signaling (by affecting CAP/SORBS1 interaction complexes), cytoskeletal dynamics, cell adhesion, and possibly antagonism or agonism of its adaptor functions in cancer or metabolic diseases.