Sorbin and SH3 domain-containing protein 2 (SORBS2)

Sorbin and SH3 domain-containing protein 2 (SORBS2) is an adaptor and RNA-binding protein characterized by an N-terminal sorbin homology (SoHo) domain and three C-terminal SH3 domains. SORBS2 is highly enriched in cardiac and skeletal muscle—localizing at intercalated discs in heart tissue, Z-bands in cardiomyocytes, and at actin stress fibers, focal adhesions, and cell junctions in other cell types. Its physiological functions include connecting integrins to the actin cytoskeleton, regulating cell adhesion, cytoskeletal organization, and signal transduction by assembling complexes involving the Abelson family of non-receptor tyrosine kinases (Arg/Abl), alpha-actinin, vinculin, flotillin, and other partners. SORBS2 expression is tightly regulated; dysregulation is associated with cardiac pathologies such as hypertrophy and fibrosis, electrical remodeling, and congenital heart defects, and also with muscular dystrophies and cancer cell migration. SORBS2 is not a classical receptor, enzyme, transporter, or ion channel, but rather a scaffolding protein involved in structural and signaling roles within the cell.

Other names

ArgBP2ARGBP2KIAA0777PRO0618sorbin and SH3 domain containing 2Arg-binding protein 2SorbinArg/Abl-interacting protein 2Arg/Abl interacting protein