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Sorbitol Dehydrogenase (SORD)
- Target
- SORD
- Molecular classification
- Enzyme, Medium-chain dehydrogenase/reductase
01
Overview
Sorbitol dehydrogenase (SORD) is a cytosolic enzyme that catalyzes the reversible oxidation of sorbitol to fructose using NAD+ as a cofactor. It plays a key role in carbohydrate metabolism, particularly in the polyol pathway. SORD is expressed ubiquitously, with highest concentrations in the liver and seminal vesicles. Clinically, it serves as a diagnostic marker for liver injury. In tissues with low expression, sorbitol accumulation can lead to diabetic complications. SORD is a therapeutic target for ischemia/reperfusion-induced liver injury and diabetic complications.
- Other names
- SDH
02
Mechanism of action
Sorbitol dehydrogenase inhibitors modulate glycolytic fluxes and apoptotic pathways.
03
Biological functions
Carbohydrate metabolismSorbitol oxidationFructose productionEnergy source for sperm motility
04
Disease associations
Diabetic complications (retinopathy, cataract, nephropathy, neuropathy)Liver diseaseLiver injury
05
Safety considerations
Sorbitol accumulation in tissues with low SDH expression leading to osmotic stress
06
Biomarkers
Elevated serum SDH levels as a marker for liver injury/disease
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