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Target intelligence / Profile preview
Sortilin (SORT1)
- Target
- SORT1
- Molecular classification
- Vacuolar protein sorting 10 (Vps10p) domain receptor family, Type I transmembrane glycoprotein, Sorting receptor, Endocytosis receptor
01
Overview
Sortilin is an essential multi-domain sorting receptor central to diverse physiological processes—especially neural function and lipid homeostasis—and represents an important node linking intracellular trafficking to human health/disease states.
02
Biological functions
Intracellular sorting/traffickingEndocytosisExosome biogenesisLipid and lipoprotein metabolismNeuronal growthNeuronal survivalNeuronal deathInflammation regulationLysosomal degradation
03
Disease associations
Coronary artery diseaseAtherosclerosisHypertensionAlzheimer’s diseaseCancer
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