Sortilin-related VPS10 domain containing receptor 2 (SorCS2)

SorCS2 (Sortilin-related VPS10 domain containing receptor 2) is a member of the VPS10 protein family, primarily expressed in the central nervous system, especially in neurons. It is a type I transmembrane glycoprotein receptor with a single transmembrane pass, a large extracellular domain containing a characteristic Vps10p domain (beta-propeller structure), and a leucine-rich repeat domain. SorCS2 acts as a multiligand receptor, binding various neurotrophic factors, amyloid precursor protein, and cytokines, thereby participating in cellular signaling and trafficking. It is crucial for neuronal viability, synaptic plasticity, and is differentially processed in neurons versus glial cells, leading to tissue-specific effects. Genetic variants in SorCS2 are associated with several psychiatric and neurodegenerative disorders, as well as differential severity in alcohol withdrawal. If specific information is required for structured drug interactions or mechanism details, further data mining is needed since current results list function and disease association, but no named clinical agents.

Other names

SorCS2KIAA1329VPS10 domain-containing receptor SorCS2sortilin related VPS10 domain containing receptor 2

Drugs targeting SorCS2 would potentially modulate neurotrophic factor signaling, endocytosis, synaptic plasticity, and may affect interactions with NGFR, BDNF (proBDNF), and related neurotrophins.