Sorting nexin 13 (SNX13)

Sorting nexin 13 (SNX13) is a multifunctional protein containing both PX (phosphoinositide-binding) and RGS (regulator of G protein signaling) domains, classifying it in both the sorting nexin and RGS protein families[1][2][3][5]. SNX13 acts as a molecular brake on cholesterol export from lysosomes and structures ER–lysosome contacts, contributing to the regulation of lipid homeostasis in cells[1]. It also serves as a GTPase activating protein specifically for Gαs, thus linking G protein–mediated signaling to vesicular trafficking processes[1][2]. SNX13 delays epidermal growth factor receptor degradation by regulating lysosomal trafficking, indicating a role in receptor sorting and lysosomal targeting[1][3]. Genetic deletion of SNX13 in mice leads to severe developmental abnormalities and embryonic lethality, primarily due to disrupted endosomal-lysosomal trafficking and nutrient uptake[3]. While SNX13 is critical to cellular homeostasis and development, there are currently no known drugs or clinical biomarkers that target or utilize this molecule[1][2][3].

Other names

RGS-PX1KIAA0713sorting nexin-13RGS domain- and PHOX domain-containing proteinSNX13

Not applicable (no drugs directly targeting SNX13 are described)