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Sorting nexin 22 (SNX22)
- Target
- SNX22
- Molecular classification
- Sorting nexin family protein, PX domain-containing protein, Cytoplasmic trafficking protein
01
Overview
Sorting nexin 22 (SNX22) is a member of the sorting nexin protein family, characterized by the PX domain responsible for phosphatidylinositol 3-phosphate membrane binding. SNX22 localizes to the cytoplasm and is implicated in intracellular protein trafficking, participating in endosomal sorting and possibly in protein quality control. Two transcript variants exist: one protein-coding, one non-coding. Diseases associated with SNX22 include brittle bone disorder and osteogenesis imperfecta type IX, although it does not appear to be a known direct therapeutic target. Members of the sorting nexin family regulate diverse functions such as vesicular transport, autophagy, and protein homeostasis, with genetic defects impacting several disease pathways, but SNX22's specific disease associations and druggability have not been thoroughly characterized.
- Other names
- SNX22FLJ13952Sorting nexin-22
02
Biological functions
Intracellular traffickingPhosphatidylinositol bindingEndosomal cargo sorting
03
Disease associations
Brittle bone disorderOsteogenesis imperfecta type IXOther (potentially broader roles inferred from sorting nexin family, such as cancer, neurodegeneration, infection)
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