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Sorting nexin-24 (SNX24)
- Target
- SNX24
- Molecular classification
- Sorting nexin family protein, Phox homology (PX) domain-containing protein
01
Overview
Sorting nexin-24 is a cytoplasmic and membrane-associated protein defined by a conserved Phox homology (PX) domain that binds phosphoinositides. SNX24 is necessary for the biogenesis and maturation of platelet α-granules, localizing to endosomal compartments and α-granules during megakaryocyte development. Knockout studies demonstrate that absence of SNX24 disrupts α-granule cargo trafficking, affecting key chemokines and glycoproteins. Variants in SNX24 are associated with altered platelet traits and cardiovascular phenotypes, and, while not a therapeutic target, it participates in essential cellular trafficking mechanisms. Dysfunction of sorting nexins in general is linked to several major disease areas including neurodegenerative disease, cancer, and cardiovascular disorders.
- Other names
- SNX24Sorting nexin 24
02
Mechanism of action
Not applicable. There are no drugs targeting SNX24, so mechanisms of action are unreported.
03
Biological functions
Intracellular traffickingα-granule biogenesis in megakaryocytesEndocytosis and endosomal sortingProtein sorting and membrane association
04
Disease associations
Platelet disorder (altered α-granules)Possible involvement in cardiovascular disease (coronary artery aneurysm in Kawasaki disease)Associations with neurodegenerative disease, cancer, and inflammation via family-wide dysfunction
05
Biomarkers
SNP rs28891 in SNX24 has been correlated with coronary artery aneurysm complications in Kawasaki diseaseSNX24 levels can affect platelet-crit and mean platelet volume
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