Sorting nexin-31 (SNX31)

Sorting nexin-31 (SNX31) is a member of the sorting nexin (SNX) family, which comprises cytoplasmic proteins primarily involved in endosomal protein trafficking and homeostasis[1][2][5]. SNX31 contains both a PX (phox-homology) domain, which binds phosphoinositides and targets the protein to membrane compartments, and a FERM (4.1/ezrin/radixin/moesin-like) domain, which enables binding to other protein partners such as β1-integrin[3]. SNX31 is highly and specifically expressed in terminally differentiated bladder urothelial umbrella cells and is co-expressed with uroplakin proteins, playing a role in the trafficking and degradation of uroplakin-rich vesicles through the multivesicular body (MVB) pathway in these cells[1]. Additionally, its interaction with β1-integrin implicates SNX31 in integrin-mediated signaling and vascular integrity, and a mutation in SNX31 has been associated with autosomal dominant familial exudative vitreoretinopathy (FEVR), a disorder of retinal vascularization[3]. SNX31 does not currently have known pharmacological modulators or established biomarker applications. Although its primary roles are in cellular trafficking and membrane homeostasis, the SNX family’s dysfunction is broadly linked to various human diseases, including neurodegenerative and vascular disorders[1][3][4].

Other names

Sorting nexin 31SNX31MGC39715