Sorting nexin-8 (SNX8)

Sorting nexin-8 (SNX8) is a member of the sorting nexin family, characterized by a conserved PX (phox homology) domain that binds to phosphoinositides, facilitating its localization to endosomal and lysosomal membranes[3]. SNX8 plays a critical role in lysosome tubulation and reformation, a process required for restoring lysosomal function and recycling lysosomal components, particularly under conditions where lysosome pools are diminished[1]. It has the ability to induce membrane curvature due to its BAR domain, and interacts with lysosomal proteins such as LAMP1. SNX8’s activity is essential for maintaining protein and organelle homeostasis via its involvement in endosomal and lysosomal pathways. Disruption of SNX8 function results in cellular phenotypes typical of lysosomal storage disorders and SNX8 deficiencies are implicated in neurodegenerative and other human diseases[1][2][3]. Overexpression or upregulation of SNX8 may rescue cellular dysfunctions associated with these pathologies, suggesting emerging therapeutic potential[1].

Other names

Sorting nexin 8SNX8Mvp1sorting nexin-8

Promotion of lysosome reformation via induction of tubulation and membrane recycling; Binding of phosphoinositides on lysosome/endosome membranes