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Target intelligence / Profile preview
SOX9 antisense RNA 1 (SOX9-AS1)
- Target
- SOX9-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
SOX9 antisense RNA 1 (SOX9-AS1) is a long non-coding RNA (lncRNA) transcribed from the genomic region antisense to the SOX9 gene. It acts as a molecular regulator, facilitating cancer cell proliferation, migration, invasion, and metastasis, notably by modulating the Wnt/β-catenin signaling pathway via a positive feedback loop involving miR-5590-3p and SOX9. SOX9-AS1 is upregulated in hepatocellular carcinoma and triple-negative breast cancer, correlating with poor prognosis and aggressive tumor behavior. Its function is exerted largely in the cytoplasm by acting as a competitive endogenous RNA (ceRNA) that sponges specific microRNAs, thus influencing the expression of SOX9 and downstream pathways implicated in cancer progression[2][3].
- Other names
- FLJ37644SOX9-AS1
02
Mechanism of action
Molecular sponge for microRNAs (e.g., miR-5590-3p) regulating SOX9 expression
03
Biological functions
Regulation of gene expressionRegulation of cell proliferationRegulation of cell migrationPromotion of epithelial-to-mesenchymal transitionRegulation of the Wnt/β-catenin signaling pathway
04
Disease associations
Cancer: Specifically hepatocellular carcinoma (HCC)Cancer: Triple-negative breast cancerOther (potentially implicated in other malignancies by regulatory mechanism)
05
Safety considerations
Safety concerns not directly described; as a regulatory lncRNA, direct targeting may carry risks of off-target gene expression effects or impact on normal cellular processes
06
Biomarkers
SOX9-AS1 expression as a prognostic biomarker in HCCPossibly in triple-negative breast cancer
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