SP100 nuclear antigen pseudogene

SP100 nuclear antigen pseudogene is a noncoding segment of DNA that closely resembles the functional SP100 gene but does not produce a functional protein. Pseudogenes like this typically arise from duplication or retrotransposition events and lack the ability to encode active proteins[3]. The functional SP100 gene encodes a nuclear protein involved in chromatin organization, immune regulation, and antiviral responses[1][2][3]. However, the pseudogene variant ENSG00000270287 does not possess these properties and is not a bona fide molecular target. The entry "SP100 nuclear antigen pseudogene" (ENSG00000270287) refers to a pseudogene, not an active protein-coding gene[3]. As such, it is not considered a therapeutic target, does not have molecular functions, interacting drugs, or clinical roles. The functional gene SP100 (SP100 nuclear antigen, ENSG00000130713) is a zinc finger nuclear protein, but this is distinct from the pseudogene. Functional SP100 has roles in chromatin regulation, immune response, and is implicated in several disease processes[1][2][3].