Sp5 transcription factor (SP5)

The Sp5 transcription factor (SP5) is a member of the Sp family of zinc finger transcription factors. It acts as a DNA-binding transcription factor, regulating transcription via RNA polymerase II and cis-regulatory region binding. SP5 is a direct WNT target gene and acts as a crucial modulator of WNT/β-catenin signaling, especially in controlling gene expression duration in developmental contexts, such as in stem cells. It is essential for the formation of primary and motile cilia across cell types, acting at the top of the transcriptional network that drives cilia gene expression. Elevated SP5 expression is associated with a variety of cancers, where it promotes tumor cell growth, migration, and metastasis, in part by regulating other oncogenic pathways. SP5's dysfunction is implicated both in cancer biology and ciliopathies—developmental disorders arising from abnormal cilia formation and function. Note: - There is no evidence SP5 is a direct target for any approved therapeutics, nor are there listed interacting drugs or defined mechanisms of action for drug targeting. - SP5's roles in cancer and cilia-associated disease make it a potential research or diagnostic biomarker, but not a direct therapeutic target at this time.

Other names

Transcription factor Sp5SP5Sp5SP5_HUMAN