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Spacer Peptide 1 (None)
- Target
- None
- Molecular classification
- Peptide, Viral protein, HIV-1 Gag polyprotein component
01
Overview
Spacer peptide 1 (SP1) is a short peptide segment found within the Gag polyprotein of HIV-1, linking the capsid (CA) and nucleocapsid (NC) domains. SP1 is crucial for viral assembly and maturation, facilitating proper formation of infectious virions. It is a target for maturation inhibitors like bevirimat, which prevent cleavage at the CA-SP1 junction, leading to non-infectious virus particles. Mutations in SP1 can affect drug sensitivity.
- Other names
- SP1SP Phe-Pro-Ala-Gly-Leu-Val-Gly-Ile-Thr-Ala-Met-Asp-LysCA-SP1 junction
02
Mechanism of action
Inhibition of CA-SP1 cleavage by HIV protease, resulting in non-infectious virions.
03
Biological functions
Viral assemblyViral maturationHIV-1 replicationLinker between CA and NC domains
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Drug resistance mutations within SP1Potential for altered sensitivity to maturation inhibitors
06
Interacting drugs
Bevirimat
1 more in the full profile.
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